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Metabolic peptides · 7 Min. Lesezeit · von T.J.

GLP-1, GIP, glucagon — peptides that act on metabolism

A plain explanation of a group of investigational peptides — semaglutide, tirzepatide and retatrutide — that mimic gut hormones and act on one, two or three switches at once.

Dieser Artikel ist derzeit nur auf Englisch verfügbar. Die deutsche Fassung folgt.

The peptides in this group are among the most intensively studied compounds affecting metabolism. They mimic the action of gut hormones and activate “switches” (receptors) in the body called GLP-1, GIP and glucagon. A receptor is the site a hormone activates to produce an effect — releasing insulin, say, or reducing appetite.

Acting on one, two or three switches

  • Semaglutide — acts on one switch: GLP-1
  • Tirzepatide — acts on two at once: GLP-1 and GIP
  • Retatrutide — acts on three at once: GLP-1, GIP and glucagon

The research context

In the scientific literature these compounds are studied for how they affect the body's handling of fat and sugar — so far under experimental conditions (research models).

Legal note

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